Discovery of 1-aryloxyethyl piperazine derivatives as Kv1. 5 potassium channel inhibitors (part I)

…, W Chen, H Chu, J Wei, X Zhang, H Sun, Y Tang…

Index: Guo, Xiaoke; Ma, Xianglei; Yang, Qian; Xu, Jing; Huang, Lu; Jia, Jianmin; Shan, Jiaojiao; Liu, Li; Chen, Weilin; Chu, Hongxi; Wei, Jinlian; Zhang, Xiaojin; Sun, Haopeng; Tang, Yiqun; You, Qidong European Journal of Medicinal Chemistry, 2014 , vol. 81, p. 89 - 94

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Citation Number: 3

Abstract

Abstract Kv1. 5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation (AF), the most common arrhythmia that threatens human. Herein, by modifying the hit compound 7k from an in-house database, 48 derivatives were synthesized for the assay of their Kv1. 5 inhibitory effects by whole cell patch clamp technique. Six compounds which showed better potency than the positive compound ...