Heterocyclic syntheses on the basis of arylation products of unsaturated compounds: X. 3-Aryl-2-chloropropanals as reagents for the synthesis of 2-amino-1, 3- …

…, VS Matiichuk, RY Vasylyshin, YV Ostapyuk

Index: Obushak; Matiichuk; Vasylyshin; Ostapyuk Russian Journal of Organic Chemistry, 2004 , vol. 40, # 3 p. 383 - 389

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Citation Number: 22

Abstract

Abstract Meerwein reaction of arenediazonium chlorides with acrolein gave 3-aryl-2- chloropropanals which were brought into cyclocondensation with thiourea. The resulting 2- amino-5-benzyl-1, 3-thiazoles were acylated with carboxylic acid chlorides and phthalic anhydride to afford, respectively, 2-acylamino-5-benzyl-1, 3-thiazoles and N-(5-benzyl-1, 3- thiazol-2-yl) phthalimides.

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