Design, Synthesis, and Anticonvulsant Activity Evaluation of 4??(3??Alkoxy??phenyl)??2, 4??dihydro??[1, 2, 4] triazol??3??ones

…, Y Zheng, SB Wang, XQ Deng, ZS Quan

Index: Shu, Bing; Zheng, Yan; Wang, Shi-Ben; Deng, Xian-Qing; Quan, Zhe-Shan Archiv der Pharmazie, 2013 , vol. 346, # 2 p. 127 - 133

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Citation Number: 9

Abstract

A series of 4-(3-alkoxy-phenyl)-2,4-dihydro-[1,2,4]triazol-3-ones were synthesized using the appropriate synthetic route and evaluated experimentally in the maximal electroshock test; their neurotoxicities were evaluated by the rotarod neurotoxicity test. The structures of these compounds were confirmed by IR, MS, 1 H-NMR, and elementary analysis. All target compounds exhibited anticonvulsant activity to varying degrees in the maximal electroshock test. ...