Structure-activity relationship of estrogens: receptor affinity and estrogen antagonist activity of certain (E)-and (2)-1, 2, 3-triaryl-2-propen-2-ones
S Mittal, S Durani, RS Kapil
Index: Mittal, Shubhra; Durani, Susheel; Kapil, Randhir S. Journal of Medicinal Chemistry, 1985 , vol. 28, # 4 p. 492 - 497
Full Text: HTML
Citation Number: 28
Abstract
(E)-and (2)-1, 2, 3-tripheny1-2-propen-l-ones and some of their phenolic and alkoxy analogues, substituted at the para position in one or more of the aromatic rings, were synthesized and assigned geometry on the basis of their spectroscopic data. The structure- activity relationship of the triarylpropenones was studied from the point of view of their estrogen receptor affinity and estrogen agonist and antagonist activities.(E)-as well as (Z)- ...
Related Articles:
[Bellina, Fabio; Carpita, Adriano; Ciucci, Donatella; De Santis, Massimo; Rossi, Renzo Tetrahedron, 1993 , vol. 49, # 21 p. 4677 - 4698]
[Diev, Vyacheslav V.; Stetsenko, Oksana N.; Tung, Tran Q.; Kopf, Juergen; Kostikov, Rafael R.; Molchanov, Alexander P. Journal of Organic Chemistry, 2008 , vol. 73, # 6 p. 2396 - 2399]
[Ku, Melih; Artok, Oezge Aksin; Ziyanak, Firat; Artok, Levent Synlett, 2008 , # 17 p. 2587 - 2592]
[Wei, Yu; Tang, Jinghua; Cong, Xuefeng; Zeng, Xiaoming Green Chemistry, 2013 , vol. 15, # 11 p. 3165 - 3169]
Pyridines. IV. A study of the Chichibabin synthesis
[Frank; Seven Journal of the American Chemical Society, 1949 , vol. 71, p. 2629,2633]