… Selective PDE4 Inhibitors. 1. Synthesis, Structure-Activity Relationships, and Molecular Modeling of 4-(3, 4-Dimethoxyphenyl)-2 H-phthalazin-1-ones and Analogues

M Van der Mey, A Hatzelmann…

Index: Fetter, J.; Lempert, K.; Moeller, J.; Nyitrai, J.; Zauer, K. Acta Chimica Hungarica, 1983 , vol. 112, # 1 p. 43 - 58

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Citation Number: 69

Abstract

... Volume: Page: ... J. Med ... Currently, a number of PDE isoenzyme families have been identified, which have been classified according to their substrate affinities and specificities (cAMP versus cGMP), kinetic characteristics (K m and V max ), subcellular distributions ...