Directed lithiation of arenethiols
K Smith, CM Lindsay, GJ Pritchard
Index: Smith,K.; Lindsay,C.M.; Pritchard,G.J. Journal of the American Chemical Society, 1989 , vol. 111, p. 665
Full Text: HTML
Citation Number: 66
Abstract
Abstract: Benzenethiol, toluene-4-thio1, and 3, 5-dimethylbenzenethiol are doubly lithiated (on sulfur and on carbon) by n-butyllithium in tetramethylethylenediamine. C-Lithiation occurs ortho to the thiol group, and subsequent treatment with electrophiles provides a convenient approach to ortho-substituted arenethiol derivatives. The reactions with tetraisopropylthiuram disulfide provide direct access to the corresponding o-phenylene ...
Related Articles:
[Baliah,V.; Uma,M. Tetrahedron, 1963 , vol. 19, p. 455 - 464]