Synthesis and evaluation of 4-alkylanilines as mammary tumor inhibiting aromatase inhibitors
RW Hartmann, C Batzl
Index: Hartmann; Batzl European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 537 - 544
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Citation Number: 7
Abstract
Abstract The 4-alkylanilines 1–20 were synthesized to elucidate the importance of the glutarimide moiety for the aromatase inhibiting activity of aminoglutethimide [3-(4- aminophenyl)-3-ethylpiperidine-2, 6-dione, AG], the only non-steroidal aromatase inhibitor which is commercially available at present. The most interesting compounds were the (4- aminophenyl) cycloalkanes 4–6 (4, c-pentyl; 5, c-hexyl; 6, c-heptyl) and the 1-alkyl-1-(4- ...
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