Bis (oxazoline) Lewis Acid Catalyzed Aldol Reactions of Pyridine N??Oxide Aldehydes—Synthesis of Optically Active 2??(1??Hydroxyalkyl) pyridine Derivatives: …

…, A Minkkilä, G Blay, KA Jørgensen

Index: Landa, Aitor; Minkkilae, Anna; Blay, Gonzalo; Jergensen, Karl Anker Chemistry - A European Journal, 2006 , vol. 12, # 13 p. 3472 - 3483

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Citation Number: 50

Abstract

Abstract A new, short, and simplified procedure for the synthesis of optically active pyridine derivatives from pro-chiral pyridine-N-oxides is presented. The catalytic and asymmetric Mukaiyama aldol reaction between ketene silyl acetals and 1-oxypyridine-2-carbaldehyde derivatives catalyzed by chiral copper (II)–bis (oxazoline) complexes gave optically active 2- (hydroxyalkyl)-and 2-(anti-1, 2-dihydroxyalkyl) pyridine derivatives in good yields and ...