Inhibition of nitric oxide synthase by benzoxazolones

K Shankaran, KL Donnelly, SK Shah, JL Humes…

Index: Shankaran; Donnelly, Karla L.; Shah, Shrenik K.; Humes, John L.; Pacholok, Stephen G.; Grant, Stephan K.; Green, Barbara G.; MacCoss, Malcolm Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 22 p. 2887 - 2892

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Citation Number: 35

Abstract

A series of benzoxazolones has been synthesized using modifications of literature methods. The synthetic benzoxazolone analogs, along with commercially available analogs, were evaluated as inhibitors of nitric oxide synthases (NOS). Structure-activity relationships are also discussed.