Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1, 3, 4-oxadiazol-2 (3H)-ones

…, F Fotiadu, S Canaan, J Leclaire, JF Cavalier

Index: Point, Vanessa; Pavan Kumar; Marc, Sylvain; Delorme, Vincent; Parsiegla, Goetz; Amara, Sawsan; Carriere, Frederic; Buono, Gerard; Fotiadu, Frederic; Canaan, Stephane; Leclaire, Julien; Cavalier, Jean-Francois European Journal of Medicinal Chemistry, 2012 , vol. 58, p. 452 - 463

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Citation Number: 19

Abstract

We report here the reactivity and selectivity of three 5-Methoxy-N-3-Phenyl substituted-1, 3, 4-Oxadiazol-2 (3H)-ones (MPOX, as well as meta and para-PhenoxyPhenyl derivatives, ie MmPPOX and MpPPOX) with respect to the inhibition of mammalian digestive lipases: dog gastric lipase (DGL), human (HPL) and porcine (PPL) pancreatic lipases, human (HPLRP2) and guinea pig (GPLRP2) pancreatic lipase-related proteins 2, human pancreatic ...