Amberlyst-15®-promoted efficient 2-halogenation of 1, 3-keto-esters and cyclic ketones using N-halosuccinimides
HM Meshram, PN Reddy, K Sadashiv, JS Yadav
Index: Meshram; Reddy; Sadashiv; Yadav Tetrahedron Letters, 2005 , vol. 46, # 4 p. 623 - 626
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Citation Number: 86
Abstract
A simple and rapid process has been developed for the α-monohalogenation of 1, 3-keto- esters with N-halosuccinimides catalyzed by Amberlyst-15® at room temperature to produce the corresponding 2-halo 1, 3-keto-esters in high yields. This protocol also extended to α- halogenation of cyclic ketones.
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