Synthesis and in vitro aldose reductase inhibitory activity of compounds containing an N-acylglycine moiety

J DeRuiter, BE Swearingen, V Wandrekar…

Index: DeRuiter, Jack; Swearingen, Blake E.; Wandrekar, Vinay; Mayfield, Charles A. Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1033 - 1038

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Citation Number: 39

Abstract

A number of N-benzoylglycines (6), N-acetyl-N-phenylglycines (7), N-benzoyl-N- phenylglycines (8), and tricyclic N-acetic acids (9-12) were synthesized as analogues of the N-acylglycine-containing aldose reductase inhibitors alrestatin and 2-oxoquinoline-1-acetic acid. Derivatives of 6, which represent ring-simplified analogues of alrestatin, are very weak inhibitors of aldose reductase obtained from rat lens, producing 50% inhibition only at ...