Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca²+/Calmoduline-Dependent Protein Kinase II

…, G Iaccarino, P Campiglia, E Novellino, C Franchini

Index: Bruno, Claudio; Lentini, Giovanni; Catalano, Alessia; Carocci, Alessia; Lovece, Angelo; Di Mola, Antonia; Cavalluzzi, Maria Maddalena; Tortorella, Paolo; Loiodice, Fulvio; Iaccarino, Guido; Campiglia, Pietro; Novellino, Ettore; Franchini, Carlo Synthesis, 2010 , # 24 art. no. T14310SS, p. 4193 - 4198

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Citation Number: 5

Abstract

Abstract Convenient synthetic routes to KN-93, N-(2-{[[(2E)-3-(4-chlorophenyl) prop-2- enyl](methyl) amino] methyl} phenyl)-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide, a well-known Ca ²+/calmoduline-dependent protein kinase II (CaMKII) inhibitor, are described. The methods proposed start from easily available reagents and allow ready preparation of the final compound in moderate overall yields. Most of the synthetic steps proposed were ...