Synthesis of Possible Cancer Chemotherapeutic Compounds Based on Enzyme Approach. III. 1, 2, 3-Oxadithiolane 2-Oxide1

HCF SU, C SEGEBARTH, KC TSOU

Index: Su,H.C.F. et al. Journal of Organic Chemistry, 1961 , vol. 26, p. 4993 - 4995

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Abstract

1, 2, 3-0xadithiolane Boxide (11) was prepared from mercaptoethanol and thionyl chloride in chloroform. The 5-methyl homolog (X) was also prepared by this method. Attempted preparation of the 5-phenyl homolog under the same conditions leads to only 2, 5-diphenyl- p-dithiane (XII). Treatment of I1 with potassium carbonate gave carbon dioxide, sulfur dioxide, and ethylene sulfide. Bromination of I1 with elemental bromine yields bis ( ...