Tetrahedron Letters

A practical and inexpensive 'convertible'isonitrile for use in multicomponent reactions

HV Le, L Fan, B Ganem

Index: Le, Hoang V.; Fan, Lijun; Ganem, Bruce Tetrahedron Letters, 2011 , vol. 52, # 17 p. 2209 - 2211

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Citation Number: 12

Abstract

N-tert-Butylamides are readily converted into the corresponding carboxylic acids by simple nitrosation. The process, which occurs under mild nonaqueous conditions, leaves carboxylic esters untouched and transforms multicomponent reaction products into useful building blocks for further synthetic elaboration.