Synthesis of piperazinyl benzothiazole/benzoxazole derivatives coupled with 1, 3, 4-oxadiazole-2-thiol: novel hybrid heterocycles as anticancer agents

MSR Murty, BR Rao, MR Katiki, LR Nath…

Index: Murty; Ramalingeswara Rao; Katiki, Mohana Rao; Nath, Lekshmi R.; Anto, Ruby John Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4980 - 4991

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Citation Number: 10

Abstract

Abstract The synthesis of a series of substituted 2-(piperazin-1-yl) benzothiazole/ benzoxazole coupled with 1, 3, 4-oxadiazole-2-thiol pharmacophore (8a–t) is described using a three carbon spacer (Jones and Helm, Drugs 69: 1903–1910, 2009). The structures of the compounds were confirmed by NMR and mass spectral data. All the synthesized compounds have been evaluated for their cytotoxicity towards five human cancer cell lines ...