Solid-phase synthesis of hydroxypiperazine derivatives using phenethylamine linker by oxidation–Cope elimination
J Seo, H Kim, CM Yoon, DC Ha, YD Gong
Index: Seo, Jin-Soo; Kim, Hye-Won; Cheol, Min Yoon; Deok, Chan Ha; Gong, Young-Dae Tetrahedron, 2005 , vol. 61, # 39 p. 9305 - 9311
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Citation Number: 7
Abstract
A general method is reported for the parallel solid-phase synthesis of hydroxypiperazine derivatives based on the oxidation–Cope elimination of polymer-bound phenethylamine linker with m-CPBA. The key intermediate of phenethylamine N-oxide resins was separable on solid-phase for subsequent β-elimination, from which the desired hydroxypiperazine products could be obtained in high purities and yields without any significant ...
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