Advanced Synthesis & Catalysis

Solvent??Free Solid Acid??Catalyzed Electrophilic Annelations: A New Green Approach for the Synthesis of Substituted Five??Membered N??Heterocycles

M Abid, A Spaeth, B Toeroek

Index: Abid, Mohammed; Spaeth, Andrew; Toeroek, Bela Advanced Synthesis and Catalysis, 2006 , vol. 348, # 15 p. 2191 - 2196

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Citation Number: 75

Abstract

Abstract An effective microwave-induced, solid acid-catalyzed, environmentally benign synthesis of substituted pyrroles, indoles and carbazoles under solvent-free conditions is described. The new synthetic methodology is based on the use of a considerably strong solid acid, K-10 montmorillonite. Both the cyclialkylation of amines and annelation of pyrroles and indoles have been completed within minutes and provided excellent (75–98 ...

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