Synthesis of potential anticancer agents. 38. N-nitrosoureas. 4. Further synthesis and evaluation of haloethyl derivatives

…, PS Opliger, WR Laster, JA Montgomery

Index: Johnston; McCaleb; Opliger; Laster; Montgomery Journal of medicinal chemistry, 1971 , vol. 14, # 17 p. 600 - 614

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Citation Number: 50

Abstract

Additional congeners of 1, 3-bi~(2-chloroethyl)-l-nitrosourea (BCSU) were 5yiithesized with special emphasii 011 alicyclic and heteroalicyclic analogs of 1-(2-chloroethy1)-3-cyclohexyl- l-riitrosourea(CCNU), which further exemplified steric control of nit, rosation. Steric control of nitrosation by~ io~ icyclic t. ertiary branching was also demonstrated.. ful only in the case of 1-(2-chloroethyl)-l-nitroso-3-(p-tolylsulfonyl) urea (51), isolatioii of characterizable nitroso ...