Synthesis, structure, and biological activity of derivatives of [2, 2]-para-cyclophane. 2. 4-Hydroxymethyl (acyloxymethyl, alkenyl)-[2, 3]-para-cyclophanes

…, SA Soldatova, EA Ageev, VN Guryshev…

Index: Mamyrbekova, Zh. A.; Bekro, Iv. A.; Soldatova, S. A.; Ageev, E. A.; Guryshev, V. N.; Soldatenkov, A. T. Pharmaceutical Chemistry Journal, 1994 , vol. 28, # 3 p. 203 - 208 Khimiko-Farmatsevticheskii Zhurnal, 1994 , vol. 28, # 3 p. 52 - 56

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Abstract

With the goal of studying the structure and biological activity of new compounds of the [2, 2]- para-cyclophane (PCP) series (I), based on its 4-acyl derivatives (II) we synthesized 4- hydroxymethyl-, 4-acyloxymethyl-, and 4-alkenyl-substituted para-cyclophanes (Ill-VII). The starting 4-acetylPCP (IIa) was obtained as in [4]. We synthesized 4-benozoylPCP (IIb) in good yield (70%) by benzoylation of PCP I with benzoyl chloride in the presence of A1C13 ...