Journal of the American Chemical Society

ETHYL-NORMAL-HEXYLBARBITURIC ACID AND OTHER DERIVATIVES OF NORMAL-HEXYLMALONIC ACID

AW Dox

Index: Dox Journal of the American Chemical Society, 1924 , vol. 46, p. 1709

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Citation Number: 6

Abstract

5, 5-Dialkylbarbituric acids, in which one alkyl is ethyl and the other methyl, ethyl, propyl, butyl, isobutyl; iso-amyl and heptyl, have been compared with respect to their hypnotic activity by Carnot and Tiffeneau. The maximum activity was manifested by the butyl, iso-butyl and iso-amyl derivatives, where the hypnotic effect was thrice that of veronal (diethylbarbituric acid). With the heptyl derivative there was a slight falling off in activity to ...