Potential neuroleptics of the orthopramide series; Synthesis of N-(3-(tert. amino) propyl)-5-sulfamoyl-2-methoxybenzamides

V Valenta, M Vlková, J Holubek, E Svátek…

Index: Valenta, Vladimir; Vlkova, Marie; Holubek, Jiri; Svatek, Emil; Metysova, Jirina; Protiva, Miroslav Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 3 p. 797 - 808

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Citation Number: 4

Abstract

Abstract Heating ethyl 5-sulfamoyl-2-methoxybenzoate with a series of twelve 3-(tert. amino) propylamines (IIIa-IIIl) afforded the title compounds IIa-IIl which were transformed to salts and subjected to pharmacological screening as potential neuroleptics of the sulpiride series. Only compounds IId (hydrogen oxalate, VUFB-15 453) and IIg (methanesulfonate, VUFB-15 397) showed indications of the desired psychotropic activity.