Synthese von 4??Alkylcytosinnucleosiden und deren cytostatische Wirkung im L1210 Leukämiemodell der Maus

…, MP Häussler, RA Schwendener

Index: Schott, Herbert; Haeussler, Markus P.; Schwendener, Reto A. Liebigs Annalen der Chemie, 1994 , # 5 p. 465 - 470

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Citation Number: 16

Abstract

4-Alkylcytosine nucleosides 2 were prepared by nucleophilic substitution of the 4-(1, 2, 4- triazol-l-y1) residue of uracil nuc-leoside derivatives 1 using different amino compounds. The antitumor activity against L1210 murine leukemia of fifteen 4-alkylcytosine nucleosides dissolved in buffer or incorporated into liposomes was tested. Liposomal l-(PD-arabinofu- ranosyl)-4-octadecylamino-2 (lH)-pyrimidinone (2d) having the highest activity gave an ...