Synthesis of Potential Anticancer Agents. XXI. Nitrosated Sulfonamides Related to Myleran

TP JOHNSTON, CL KUSSNER…

Index: Johnston,T.P. et al. Journal of Organic Chemistry, 1960 , vol. 25, p. 399 - 402

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Citation Number: 10

Abstract

Current interest in the anticancer activity exhibited by 1-methyl-3-nitro-l-nitrosoguanidine2~ 3 and particularly by l-methyl-l-nitrosourea3 against Leukemia L1210 in mice has focused attention on other N-nitroso compounds, such as N-nitrososulfonamide~,~ that have the common property of undergoing basic decomposition to give diazomethane. In the search for possible new anticancer agents containing a methyl-N-nitrosoamino group, a logical ...