Organic letters

Palladium-Catalyzed Sequential C–N/C–O Bond Formations: Synthesis of Oxazole Derivatives from Amides and Ketones

M Zheng, L Huang, H Huang, X Li, W Wu…

Index: Zheng, Meifang; Huang, Liangbin; Wu, Wanqing; Jiang, Huanfeng Organic Letters, 2013 , vol. 15, # 8 p. 1838 - 1841

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Citation Number: 14

Abstract

A highly efficient method for the synthesis of oxazole derivatives from simple amides and ketones has been established via a Pd (II)-catalyzed sp2 C–H activation pathway in one step. The reaction is supposed to proceed through a C–N bond formation followed by a C–O bond formation closing the ring. Because of the simple and readily available starting materials, easy operation, and high bioactivity of oxazoles, this strategy can be broadly ...