Improved synthesis, antibacterial activity and potential carcinogenicity of 5-amino-1, 2, 4-thiadiazol-3 (2H)-one

A Piskala, A Vachalkova, M Masojidkova…

Index: Piskala; Vachalkova; Masojidkova; Horvathova; Ovesna; Paces; Novotny, Ladislav Pharmazie, 2004 , vol. 59, # 10 p. 756 - 762

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Citation Number: 7

Abstract

This paper reports on the preparation of 5-amino-1, 2, 4-thiadiazol-3 (2H)-one, a sulfur- containing analogue of cytosine with the—CH= CH—group between the positions 5 and 6 of the pyrimidine ring replaced by the divalent sulfur (—S—). Improved procedures for the preparation of thiobiuret, some of its methyl derivatives and 5-amino-1, 2, 4-thiadiazol-3 (2H)- one are documented. Thiobiuret and its N-methyl derivatives were obtained by addition of ...