The 4-azidobenzyloxycarbonyl function; application as a novel protecting group and potential prodrug modification for amines

…, E Evers, R Davison, AE Gibson, D Layton…

Index: Griffin, Roger J.; Evers, Elaine; Davison, Richard; Gibson, Ashleigh E.; Layton, Deborah; Irwin, William J. Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 11 p. 1205 - 1211

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Citation Number: 30

Abstract

A series of 4-azidobenzylcarbamates [4-N-CH-CH-O-CO-N (H)-CH-X; X= H, Me, MeO, Br, Cl, NO] have been prepared in good yield, and in high purity, by reaction of 4-azidobenzyl alcohol with the corresponding aryl isocyanate, or by displacement of 4-nitrophenol from 4- azidobenzyl-4-nitrophenylcarbonate by the appropria