Cardiotonic agents. 1. Synthesis and structure-activity relationships in a new class of 3-, 4-and 5-pyridyl-2 (1H)-quinolone derivatives

…, G Marciniak, N Decker, J Schwartz

Index: Leclerc, Gerard; Marciniak, Gilbert; Decker, Nicole; Schwartz, Jean Journal of Medicinal Chemistry, 1986 , vol. 29, # 12 p. 2427 - 2432

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Citation Number: 32

Abstract

A series of 3-, 4-, and 5-pyridyl-2 (1H)-quinolone derivatives with H or HO or CH30 substituents in the 8-position were prepared and tested for positive inotropic activity. Several derivatives, especially 29, Sb, and 27 with a pyridyl ring in the 5-position, were ca. 2-10 times more potent on left guinea pig atria than sulmazole (ARL-115) and milrinone used as references. Some structure-activity relationships are discussed.