Tetrahedron Letters

A new synthesis of (±)-homosarkomycin ethyl ester

A Samarat, V Fargeas, J Villiéras, J Lebreton, H Amri

Index: Samarat, Ali; Fargeas, Valerie; Villieras, Jean; Lebreton, Jacques; Amri, Hassen Tetrahedron Letters, 2001 , vol. 42, # 7 p. 1273 - 1274

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Citation Number: 19

Abstract

Sarkomycin is known to display a powerful inhibitory effect on Ehrlich ascites tumors in mice. 1 As a result of the biological activities associated with sarkomycin and some analogues, among them homosarkomycin, 2., and many syntheses of these targets have been reported as multi-step syntheses 3., , , 4., 5., , and with low overall yields. We have previously described a short large-scale synthesis of (±)-sarkomycin esters 6 and derivatives 7 including a cyclic ...