Copper-catalyzed hydrative amide synthesis with terminal alkyne, sulfonyl azide, and water

SH Cho, EJ Yoo, I Bae, S Chang

Index: Cho, Seung Hwan; Yoo, Eun Jeong; Bae, Imhyuck; Chang, Sukbok Journal of the American Chemical Society, 2005 , vol. 127, # 46 p. 16046 - 16047

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Citation Number: 296

Abstract

It is shown for the first time that N-sulfonyl amides can be efficiently prepared by an unconventional approach of the hydrative reaction between terminal alkynes, sulfonyl azides, and water in the presence of copper catalyst and amine base under very mild conditions. The present route is quite general, and a wide range of alkynes and sulfonyl azides are readily coupled catalytically with water to furnish amides in high yields. A ...