Synthesis and reactivity of 1-substituted 2-fluoro-and 2, 2-difluoroaziridines
…, F Colpaert, E Van Hende, N De Kimpe
Index: Verniest, Guido; Colpaert, Filip; Van Hende, Eva; De Kimpe, Norbert Journal of Organic Chemistry, 2007 , vol. 72, # 22 p. 8569 - 8572
Full Text: HTML
Citation Number: 21
Abstract
A straightforward synthesis toward 2-fluorinated aziridines was developed via ring closure of β-fluorinated β-chloroamines, which were obtained via reduction of the corresponding α- fluorinated amides by borane. When 1-benzyl-2-fluoroaziridine was treated with methanol, reaction occurred at the 2-position, giving rise to N-benzyl-2, 2-dimethoxyethylamine, while in the case of 1-benzyl-2, 2-difluoroaziridine the 3-position was attacked, giving rise to N- ...
Related Articles:
New Compounds. Preparation of N-Substituted Aminoacetals
[Kaye; Minsky Journal of the American Chemical Society, 1949 , vol. 71, p. 2272]
[Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494]
[Kruse; Kaiser; DeWolf Jr.; Frazee; Ross; Wawro; Wise; Flaim; Sawyer; Erickson Journal of Medicinal Chemistry, 1987 , vol. 30, # 3 p. 486 - 494]
Antimalarial activities of new guanidylimidazole and guanidylimidazoline derivatives
[Zhang, Liang; Sathunuru, Ramadas; Caridha, Diana; Pybus, Brandon; O'Neil, Michael T.; Kozar, Michael P.; Lin, Ai J. Journal of Medicinal Chemistry, 2011 , vol. 54, # 19 p. 6634 - 6646]