Synthesis and biological evaluation of 4-nitro-substituted 1, 3-diaryltriazenes as a novel class of potent antitumor agents

…, A Brozovic, I Piantanida, G Fritz, A Virag…

Index: Cimbora-Zovko, Tamara; Brozovic, Anamaria; Piantanida, Ivo; Fritz, Gerhard; Virag, Andrej; Alic, Branko; Majce, Vita; Kocevar, Marijan; Polanc, Slovenko; Osmak, Maja European Journal of Medicinal Chemistry, 2011 , vol. 46, # 7 p. 2971 - 2983

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Citation Number: 13

Abstract

Abstract We describe the synthesis and biological activity of a new class of 1, 3- diaryltriazenes, namely 4-nitro-substituted 1, 3-diaryltriazenes. Structure–activity relationship analysis reveals that 1, 3-diaryltriazenes can be modified from inactive to highly cytotoxic ...