The anti-cancer, anti-inflammatory and tuberculostatic activities of a series of 6, 7-substituted-5, 8-quinolinequinones

…, EM Dangerfield, CH Plunkett, MV Berridge…

Index: Mulchin, Benjamin J.; Newton, Christopher G.; Baty, James W.; Grasso, Carole H.; Martin, William John; Walton, Michaela C.; Dangerfield, Emma M.; Plunkett, Catherine H.; Berridge, Michael V.; Harper, Jacquie L.; Timmer, Mattie S.M.; Stocker, Bridget L. Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 9 p. 3238 - 3251

Full Text: HTML

Citation Number: 25

Abstract

A variety of 6, 7-substituted-5, 8-quinolinequinones were synthesised and assessed for their anti-tumour and anti-inflammatory activities, and their ability to inhibit the growth of Mycobacterium bovis BCG. In particular, the introduction of a sulfur group at the 7-position of the quinolinequinone led to the discovery of two compounds, 6-methylamino-7- methylsulfanyl-5, 8-quinolinequinone (10a) and 6-amino-7-methylsulfonyl-5, 8- ...