Organic letters

Mesityllithium as a reagent for chemoselective halogen-lithium exchange reaction

…, M Asai, T Miura, M Uchiyama, T Sakamoto

Index: Kondo; Asai; Miura; Uchiyama; Sakamoto Organic letters, 2001 , vol. 3, # 1 p. 13 - 15

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Citation Number: 51

Abstract

Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1, 2-addition.