Synthesis and pharmacological study of new calcium antagonists, analogues of cinnarizine and flunarizine
…, G Baziard-Mouysset, G de Saqui-Sannes…
Index: Younes, S.; Baziard-Mouysset, G.; Saqui-Sannes, G. de; Stigliani, J. L.; Payard, M.; et al. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 12 p. 943 - 948
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Citation Number: 10
Abstract
Abstract Several phosphonic diethyl esters were synthesized and their calcium antagonistic activity evaluated in vitro. The diethyl phosphonate group was condensed on substituted [diphenylmethyl],[(2-benzofuranyl) phenylmethyl],[(4-(diphenylmethyl-1-piperazinyl) methyl],[4 (4-diphenylmethyl-1-piperazinyl methyl) phenylmethyl], and [4-(3-phenyl-2- propenyl)-1-piperazinyl methyl] groups. Despite the presence of the diethyl phosphonate ...
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