Biosynthesis of the Cephalotaxus alkaloids. Investigations of the biosynthesis of deoxyharringtonine, isoharringtonine, and harringtonine

…, RF Dufresne, DD Sternbach, MD Cabelli

Index: Gitterman, Amy; Parry, Ronald J.; Dufresne, Richard F.; Sternbach, Daniel D.; Cabelli, Michael D. Journal of the American Chemical Society, 1980 , vol. 102, # 6 p. 2074 - 2081

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Citation Number: 17

Abstract

Abstract: Precursor incorporation experiments have been used to investigate the biosynthesis of the antitumor Cephalotaxus alkaloids deoxyharringtonine (2), isoharringtonine (3), and harringtonine (4). It has been established that the acyl portion of deoxyharringtonine is derived from leucine via a pathway that resembles the conversion of valine into leucine in microbial sys-tems. Incorporation experiments with~~-[9-'~ C] ...