Synthesis of 2-substituted pyrimidines via cross-coupling reaction of pyrimidin-2-yl sulfonates with nucleophiles in polyethylene glycol 400
XC Wang, GJ Yang, ZJ Quan, PY Ji, JL Liang, RG Ren
Index: Wang, Xi-Cun; Yang, Guo-Jun; Quan, Zheng-Jun; Ji, Peng-Yan; Liang, Jun-Ling; Ren, Rong-Guo Synlett, 2010 , # 11 p. 1657 - 1660
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Citation Number: 15
Abstract
Abstract A mild and rapid procedure to the synthesis of 2-substituted pyrimidines was developed via sequential functionalization of easily available Biginelli 3, 4- dihydropyrimidine-2 (1H)-ones via oxidation, esterification, followed by cross-coupling reaction of pyrimidin-2-yl sulfonates with N, S, and O nucleophiles in PEG-400 as a green reaction medium at room temperature.
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