Mixing with microwaves: solvent-free and catalyst-free synthesis of pyrazoles and diazepines
BR Vaddula, RS Varma, J Leazer
Index: Vaddula, Buchi Reddy; Varma, Rajender S.; Leazer, John Tetrahedron Letters, 2013 , vol. 54, # 12 p. 1538 - 1541
Full Text: HTML
Citation Number: 24
Abstract
A simple and facile condensation of hydrazines/hydrazides and diamines with 1, 3- diketones/β-ketoester leads to the preparation of pyrazoles and diazepines in high yields. This eco-friendly protocol is accelerated by microwave heating and efficiently carried out without any reaction solvent or catalyst in as little as 5min.
Related Articles:
Efficient N-arylation catalyzed by a copper (I) pyrazolyl-nicotinic acid system
[Liu, Hai-Yang; Yu, Zhen-Tao; Yuan, Yong-Jun; Yu, Tao; Zou, Zhi-Gang Tetrahedron, 2010 , vol. 66, # 47 p. 9141 - 9144]
Diazirines as potent electrophilic nitrogen sources: Application to the synthesis of pyrazoles
[Organic Letters, , vol. 16, # 2 p. 596 - 599]
[Crawford, Sarah M.; Lavery, Christopher B.; Stradiotto, Mark Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16760 - 16771]
[Kantam, Mannepalli Lakshmi; Venkanna, Gopaladasu Tirupati; Kumar, Kota Balaji Shiva; Subrahmanyam, Vura Bala Helvetica Chimica Acta, 2010 , vol. 93, # 5 p. 974 - 979]
Synthesis of silylated β-enaminones and applications to the synthesis of silyl heterocycles
[Tetrahedron Letters, , vol. 42, # 51 p. 8981 - 8984]