Synthesis and Aminolysis of N, N-Diethyl Carbamic Ester of HOBt Derivatives

…, EA Hamed, F Albericio, A El-Faham

Index: Khattab, Sherine Nabil; Hassan, Seham Yassin; Hamed, Ezzat Awad; Albericio, Fernando; Ayman, El-Faham Bulletin of the Korean Chemical Society, 2010 , vol. 31, # 1 p. 75 - 81

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Citation Number: 6

Abstract

The reaction of N, N-diethyl carbamates of 1H-[1, 2, 3] triazolo [4, 5-b] pyridin-1-ol (4-HOAt) 7, 3H-[1, 2, 3] triazolo [4, 5-b] pyridin-3-ol (7-HOAt) 8, 1H-benzo [d][1, 2, 3] triazol-1-ol (HOBt) 9, 6-chloro-1H-benzo [d][1, 2, 3] triazol-1-ol (Cl-HOBt) 10, 6-(trifluoromethyl)-1H-benzo [d][1, 2, 3] triazol-1-ol (CF3-HOBt) 11, and 6-nitro-1H-benzo [d][1, 2, 3] triazol-1-ol (NO2-HOBt) 12 with morpholine and piperidine in CH3CN underwent acyl nucleophilic substitution to give ...