Piperazinylalkyl heterocycles as potential antipsychotic agents

MK Scott, EW Baxter, DJ Bennett, RE Boyd…

Index: Scott, Malcolm K.; Baxter, Ellen W.; Bennett, Debra J.; Boyd, Robert E.; Blum, Paul S.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 21 p. 4198 - 4210

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Citation Number: 28

Abstract

We recently reported on a series of pyrrole Mannich bases orally active in inhibiting the conditioned avoidance response (CAR) in rats. These compounds exhibit affinity for both D2 and~-HT~ A receptors, and some are noncataleptogenic. Such a profile suggests that they may be potential antipsychotic agents which lack the propensity for causing extrapyramidal side effects and tardive dyskinesias in humans. One of these compounds, l-[[l-methyl-5-[[4- ...