Synthesis and antimalarial effects of N2-aryl-N4-[(dialkylamino) alkyl]-and N4-aryl-N2-[(dialkylamino) alkyl]-2, 4-quinazolinediamines

EF Elslager, C Hess, J Johnson, D Ortwine…

Index: Elslager; Hess; Johnson; Ortwine; Chu; Werbel Journal of Medicinal Chemistry, 1981 , vol. 24, # 2 p. 127 - 140

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Citation Number: 25

Abstract

Chemistry. The synthetic approach utilized for the preparation of the N44 (dialky1amino) alkyll-W-phenyl-2, 4-quinazolinediamines (VI) involved modifications of previous5p6 procedures and is depicted in Scheme I. Condensation of the appropriate 2, 4- dichloroquinazoline (IV) with the requisite N, N-dialkylalkylenediamine in ether, alcohol- ether, alcohol, nitrobenzene, or dilute aqueous sodium hydroxide5 generated the ...