Bulky trialkylsilyl acetylenes in the Cadiot-Chodkiewicz cross-coupling reaction
JP Marino, HN Nguyen
Index: Marino, Joseph P.; Nguyen, Hanh Nho Journal of Organic Chemistry, 2002 , vol. 67, # 19 p. 6841 - 6844
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Citation Number: 96
Abstract
Bulky trialkylsilyl-protected alkynes such as triethylsilyl (TES), tert-butyldimethylsilyl (TBS), and triisopropylsilyl (TIPS) acetylenes underwent the Cadiot-Chodkiewicz cross-coupling reaction with different bromoalkynes to form a variety of synthetically useful unsymmetrical diynes in good yields. The diyne alcohol 10 was transformed regio-and stereoselectively into enynes by hydrotelluration, carbometalation, and reduction reactions.
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