Synthesis of 2??amino??6??chloro??and 2, 6??diammopunne 3??oxides

I Scheinfeld, JC Parham…

Index: Scheinfeld; Parham; Bosworth Brown Journal of Heterocyclic Chemistry, 1982 , vol. 19, # 5 p. 1231 - 1233

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Citation Number: 2

Abstract

Abstract N-Oxidation of 2-amino-6-chloropurine to the 3-oxide provided a convenient intermediate for the synthesis of 2-amino-6-substituted purine 3-oxides, including the previously unavailable 2, 6-diaminopurine 3-oxide. Thiation of the 6-halogen was accompanied by reduction of the N-oxide. The properties of the 1-and 3-oxides of 2, 6- diaminopurine are compared.