Deamination of 5′-substituted-2′, 3′-isopropylidene adenosine derivatives catalyzed by adenosine deaminase (ADA, EC 3.5. 4.4) and complementary enzymatic …

P Ciuffreda, A Loseto, E Santaniello

Index: Ciuffreda, Pierangela; Loseto, Angela; Santaniello, Enzo Tetrahedron, 2002 , vol. 58, # 29 p. 5767 - 5771

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Citation Number: 32

Abstract

Adenosine deaminase (ADA) catalyzes the deamination of 2′, 3′-isopropylidene adenosine and the corresponding 5′-amino derivative in a 3% dimethylsulfoxide aqueous solution. Whereas ADA is unable to convert other 5′-substituted derivatives (acetate, acetamido, azide), the enzyme adenylate deaminase (AMPDA) accepts all the above compounds as substrates for their biotransformation to the corresponding 5′-substituted ...