Synthesis of 2 H-indazoles by the [3+ 2] dipolar cycloaddition of sydnones with arynes

Y Fang, C Wu, RC Larock, F Shi

Index: Fang, Yuesi; Wu, Chunrui; Larock, Richard C.; Shi, Feng Journal of Organic Chemistry, 2011 , vol. 76, # 21 p. 8840 - 8851

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Citation Number: 44

Abstract

A rapid and efficient synthesis of 2 H-indazoles has been developed using a [3+ 2] dipolar cycloaddition of sydnones and arynes. A series of 2 H-indazoles have been prepared in good to excellent yields using this protocol, and subsequent Pd-catalyzed coupling reactions can be applied to the halogenated products to generate a structurally diverse library of indazoles.