Electrophilic Chemistry of Biologically Important α-Ketoacids

…, S Lau, M Garza, B Schick, K Kantardjieff

Index: Klumpp, Douglas A.; Lau, Siufu; Garza, Manuel; Schick, Brian; Kantardjieff, Katherine Journal of Organic Chemistry, 1999 , vol. 64, # 20 p. 7635 - 7637

Full Text: HTML

Citation Number: 20

Abstract

The R-ketoacids 1-4 and their deprotonated anions play central roles in a number of biochemical processes. 1-4 Despite the importance of the R-ketoacids, little work has been done to evaluate these compounds in their reactivities toward weak nucleophiles such as aromatic compounds. Recently, there has been a considerable amount of interest in the generation of strong electrophiles from 1, 2-dicarbonyl systems and the ability of these ...