Chronobiotic activity of N-[2-(2, 7-dimethoxyfluoren-9-yl) ethyl]-propanamide. Synthesis and melatonergic pharmacology of fluoren-9-ylethyl amides

JR Epperson, MA Bruce, JD Catt, JA Deskus…

Index: Epperson, James R.; Bruce, Marc A.; Catt, John D.; Deskus, Jeffrey A.; Hodges, Donald B.; Karageorge, George N.; Keavy, Daniel J.; Mahle, Cathy D.; Mattson, Ronald J.; Ortiz, Astrid A.; Parker, Michael F.; Takaki, Katherine S.; Watson, Brett T.; Yevich, Joseph P. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4601 - 4611

Full Text: HTML

Citation Number: 11

Abstract

A series of fluoren-9-yl ethyl amides (2) were synthesized and evaluated for human melatonin MT1 and MT2 receptor binding. N-[2-(2, 7-dimethoxyfluoren-9-yl) ethyl] propanamide (2b) was selected and evaluated in functional assays measuring intrinsic activity at the human MT1 and MT2 receptors and demonstrated full agonism at both receptors. The chronobiotic properties of 2b were demonstrated in both acute and chronic ...

Related Articles:

Cross dehydrogenative coupling via base-promoted homolytic aromatic substitution (BHAS): synthesis of fluorenones and xanthones

[Wertz, Sebastian; Leifert, Dirk; Studer, Armido Organic Letters, 2013 , vol. 15, # 4 p. 928 - 931]

Cross dehydrogenative coupling via base-promoted homolytic aromatic substitution (BHAS): synthesis of fluorenones and xanthones

[Wertz, Sebastian; Leifert, Dirk; Studer, Armido Organic Letters, 2013 , vol. 15, # 4 p. 928 - 931]

The mechanisms of long-range 13C, 19F and 19F, 19F coupling constants in derivatives of biphenyl and fluorene. Differential isotope shifts

[Schaefer, Ted; Peeling, James; Penner, Glenn H. Canadian Journal of Chemistry, 1986 , vol. 64, p. 2162 - 2167]

The Michael Reaction of Fluoro-substituted-9, 9′-Bifluorenylidenes and-Fluorenes, and the Syntheses of Some Related Compounds

[Minabe,M. et al. Bulletin of the Chemical Society of Japan, 1971 , vol. 44, p. 1614 - 1619]

More Articles...