Synthesis of β??Keto Esters Promoted by Yttria??Zirconia Based Lewis Acid Catalyst

RK Pandey, AN Deshmukh, P Kumar

Index: Pandey, Rajesh K.; Deshmukh, Anis N.; Kumar, Pradeep Synthetic Communications, 2004 , vol. 34, # 6 p. 1117 - 1123

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Citation Number: 5

Abstract

The condensation of aldehydes with methyl/ethyl diazoacetate in the presence of catalytic amount of yttria??zirconia based Lewis acid afforded the corresponding ß??keto esters in good to excellent yields (Table 1). The aliphatic aldehyde reacted faster than aromatic (Table 1, entry 1). The substitution pattern in the aromatic ring has distinctive influence on the rate of reaction. For example, the aromatic aldehyde with electron donating substituents accelerated the reaction (Table 1, ...