Chemical communications

One-pot β-substitution of enones with alkyl groups to β-alkyl enones

J Matsuo, Y Aizawa

Index: Matsuo, Jun-Ichi; Aizawa, Yayoi Chemical Communications, 2005 , # 18 p. 2399 - 2401

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Citation Number: 6

Abstract

Vinylic hydrogens at the β-position of enones were effectively substituted with alkyl groups in a one-pot procedure to afford β-alkyl enones in good to high isolated yields by conjugate addition of higher-order dialkyl cyanocuprates to enones, followed by a reaction with N-tert- butylbenzenesulfinimidoyl chloride at− 78° C.