Il Farmaco

Synthesis of amides with anti-inflammatory and analgesic activities

…, GAM Pintore, W Filippelli, G Falcone, F Palagiano…

Index: Pau; Cerri; Boatto; Palomba; Pintore; Filippelli; Falcone; Palagiano; Rossi Farmaco, 1997 , vol. 52, # 2 p. 93 - 98

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Citation Number: 6

Abstract

A series of N-Aroyl-cyclohexyl-and cyclohexenylamides 3-or 4-methylsubstituted were synthesized and evaluated for their anti-inflammatory and analgesic potencies, and gastrointestinal irritation liability. One compound, N-benzoyl-4-methyl-cyclohexylamide 6a, possessed an anti-inflammatory activity comparable to that of indomethacin.